特徴
- 背景：Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition; NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：O14931
- タグ種類：C-Fc
- アミノ酸配列：Leu19-Thr138
- 遺伝子構造：Recombinant Human Natural Cytotoxicity Triggering Receptor 3 is produced by our Mammalian expression system and the target gene encoding Leu19-Thr138 is expressed with a Fc tag at the C-terminus.
- 別名（遺伝子名）：Natural Cytotoxicity Triggering Receptor 3; Activating Natural Killer Receptor p30; Natural Killer Cell p30-Related Protein; NK-p30; NKp30; CD337; NCR3; 1C7; LY117;1C7;DAAP-90L16.3;MALS
- 分子量：40.2 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB;150mM NaCl;pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106496-Elabscience-PKSH032787.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7787-18
Recombinant Human NCR3/NKp300 Protein (Fc Tag) 10ug
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89-7787-19
Recombinant Human NCR3/NKp300 Protein (Fc Tag) 50ug
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