89-7785-77 Recombinant Human LR3-IGF-1 Protein (MG)(Active) 50ug PKSH032712
[Elabscience]
特徴
- 背景：Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins; which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR; IGF-IIR; and the insulin receptor and plays a key role in cell cycle progression; cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three; hence R3; and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P05019
- アミノ酸配列：Gly49-Ala118 (Glu51Arg)
- 遺伝子構造：Recombinant Human LR3 Insulin-Like Growth Factor-I is produced by our E.coli expression system and the target gene encoding Gly49-Ala118 (Glu51Arg) is expressed.
- 活性：Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is 0.2-1.5 ng/ml.
- 別名（遺伝子名）：Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1
- 分子量：9.1 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 300mM HAc-NaAc; pH 6.5.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106425-Elabscience-PKSH032712.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7785-77
Recombinant Human LR3-IGF-1 Protein (MG)(Active) 50ug
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89-7785-76
Recombinant Human LR3-IGF-1 Protein (MG)(Active) 10ug
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