89-7784-55 Recombinant Human IL5RA/IL-5 Ra Protein (His Tag) 10ug PKSH032651
[Elabscience]
特徴
- 背景：Interleukin-5 Receptor alpha (IL-5Ra; CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 Ra consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif; a 20 aa transmembrane segment; and a 58 aa cytoplasmic domain. Within the ECD; human IL-5Ra shares 71% aa sequence identity with mouse and rat IL-5 Ra. Alternate splicing of human IL-5 Ra generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Ra and the transmembrane common b chain (bc/CD131) which is shared with the receptor complexes for IL-3 and GMCSF. IL-5 Ra binds IL-5 at low affinity and then associates with preformed bc oligomers to form the signaling competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5Ra followed by eosinophilic differentiation and activation.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q01344
- タグ種類：C-6His
- アミノ酸配列：Asp21-Glu335
- 遺伝子構造：Recombinant Human Interleukin-5 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Asp21-Glu335 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Interleukin-5 receptor subunit alpha; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5RA; IL5R;HSIL5R3;IL5R
- 分子量：36.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106365-Elabscience-PKSH032651.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7784-55
Recombinant Human IL5RA/IL-5 Ra Protein (His Tag) 10ug
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89-7784-56
Recombinant Human IL5RA/IL-5 Ra Protein (His Tag) 50ug
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