89-7784-28 Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG2 Fc)(Active) 50ug PKSH032632
[Elabscience]
特徴
- 背景：Interleukin-22(IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q9GZX6
- タグ種類：C-hIgG2 Fc
- アミノ酸配列：Ala34-Ile179
- 遺伝子構造：Recombinant Human Interleukin-22 is produced by our Mammalian expression system and the target gene encoding Ala34-Ile179 is expressed with a hIgG2 Fc tag at the C-terminus.
- 活性：Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 90.41 ng/ml.
- 別名（遺伝子名）：Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF; IL22;IL-D110;IL-TIF;ILTIF;TIFa;TIFIL-23;zcyto18
- 分子量：43.4 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106351-Elabscience-PKSH032632.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7784-27
Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG2 Fc)(Active) 10ug
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89-7784-28
Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG2 Fc)(Active) 50ug
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