89-7783-80 Recombinant Human IFNAR1/IFNAR Protein (His Tag)(Active) 10ug PKSH032604
[Elabscience]
特徴
- 背景：The Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-α and -β. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN-α/β R1, in association with IFN-α/β R2, is required for propagating antiviral signal transduction triggered by IFN-α and IFN-β. IFN-α/β R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-α/β R2. Ligands associate with IFN-α/β R2, and this complex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γ R2 even in the absence of IFN-γ stimulation. Human IFN-α/β R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P17181
- タグ種類：C-6His
- アミノ酸配列：Lys28-Lys436
- 遺伝子構造：Recombinant Human Interferon alpha/beta Receptor 1 is produced by our Mammalian expression system and the target gene encoding Lys28-Lys436 is expressed with a 6His tag at the C-terminus.
- 活性：Immobilized Human IFN alpha2b(Cat: PKSH033640) at 2μg/ml(100 μl/well) can bind Human IFNAR1-His.
- 別名（遺伝子名）：Interferon Alpha/Beta Receptor 1; IFN-R-1; IFN-Alpha/Beta Receptor 1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; CRF2-1; Type I Interferon Receptor 1;IFNAR1;IFNAR;AVP;IFN-alpha-REC
- 分子量：48.2 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106328-Elabscience-PKSH032604.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7783-81
Recombinant Human IFNAR1/IFNAR Protein (His Tag)(Active) 50ug
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89-7783-80
Recombinant Human IFNAR1/IFNAR Protein (His Tag)(Active) 10ug
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