89-7783-44 Recombinant Human IDO1/IDO Protein (His Tag)(Active) 10ug PKSH032584
[Elabscience]
特徴
- 背景：Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P14902
- タグ種類：N-6His
- アミノ酸配列：Met 1-Gly403
- 遺伝子構造：Recombinant Human Indoleamine 2,3-dioxygenase is produced by our E.coli expression system and the target gene encoding Met1-Gly403 is expressed with a 6His tag at the N-terminus.
- 活性：Measured by its ability to oxidize L-tryptophan to N-formyl-kynurenine. The specific activity is 5166.667 pmol/min/ug pmol/min/μg.
- 別名（遺伝子名）：Indole 2;3-dioxygenase; Indoleamine 2;3-dioxygenase 1; IDO-1; IDO1; IDO; INDO
- 分子量：46.8 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM Sodium Acetate, 150mM NaCl and 20% Glycerol, pH4.5.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106309-Elabscience-PKSH032584.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7783-45
Recombinant Human IDO1/IDO Protein (His Tag)(Active) 50ug
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89-7783-44
Recombinant Human IDO1/IDO Protein (His Tag)(Active) 10ug
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