89-7782-89 ［取扱停止］Recombinant Human IA2/PTPRN Protein (aa 576-950, His Tag) 10ug PKSH032554
[Elabscience]
特徴
- 背景：Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain; is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules; such as their biogenesis; trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity; may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera; and thus may be a potential target of autoimmunity in diabetes mellitus.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q16849
- タグ種類：N-6His
- アミノ酸配列：Arg576-Gln950
- 遺伝子構造：Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N is produced by our E.coli expression system and the target gene encoding Arg576-Gln950 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512
- 分子量：44.6 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM Tris;150mM NaCl;pH8.0.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106282-Elabscience-PKSH032554.pdf
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89-7782-89
Recombinant Human IA2/PTPRN Protein (aa 576-950, His Tag) 10ug
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89-7782-90
Recombinant Human IA2/PTPRN Protein (aa 576-950, His Tag) 50ug
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