89-7782-43　Recombinant Human HO-1/HMOX1 Protein 10ug　PKSH032529

特徴

• 背景：Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.

仕様

• サイズ：10ug
• 種由来：Human
• 発現宿主：E.coli
• 純度：> 95 % as determined by reducing SDS-PAGE.
• エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
• アクセッションＮｏ．：P09601
• アミノ酸配列：Met 1-Thr 261
• 遺伝子構造：Recombinant Human Heme Oxygenase 1 is produced by our E.coli expression system and the target gene encoding Met1-Thr261 is expressed.
• 別名（遺伝子名）：Heme Oxygenase 1; HO-1; HMOX1; HO; HO1
• 分子量：29.9 kDa
• 組成：Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.4.
• 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106259-Elabscience-PKSH032529.pdf
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