89-7780-41 Recombinant Human CD32a/FCGR2A Protein (H131, His Tag)(Active) 10ug PKSH032418
[Elabscience]
特徴
- 背景：Human FcγRs are divided into three classes designated FcγRI (CD64); FcγRII (CD32); and FcγRIII (CD16); which generate multiple isoforms; are recognized. The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses; whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.Human CD32; also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a); FcγRII A or FCGR2A Protein; is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit; FcRγ; CD32a (FcγRII A) delivers an activating signal upon ligand binding; and results in the initiation of inflammatory responses including cytolysis; phagocytosis; degranulation; and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B; and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P12318
- タグ種類：C-6His
- アミノ酸配列：Ala36-Ile218(His131Arg)
- 遺伝子構造：Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A is produced by our Mammalian expression system and the target gene encoding Ala36-Ile218(His131Arg) is expressed with a 6His tag at the C-terminus.
- 活性：Immobilized Human IgG1-Fc(Cat: PKSH032558) at 2μg/ml(100 μl/well) can bind Human CD32a-His.
- 別名（遺伝子名）：Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD32; FCGR2A; FCG2; FCGR2A1;IGFR2;CD32A;CDw32;Fc gamma RIIA;FCG2;FcGR;FCGR2
- 分子量：21.1 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106160-Elabscience-PKSH032418.pdf
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
89-7780-41
Recombinant Human CD32a/FCGR2A Protein (H131, His Tag)(Active) 10ug
|
|
|
89-7780-42
Recombinant Human CD32a/FCGR2A Protein (H131, His Tag)(Active) 50ug
|
よくあるご質問（FAQ）
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|