89-7780-03 Recombinant Human EGFR/ErbB1 Protein (aa 25-645, Fc Tag)(Active) 10ug PKSH032398
[Elabscience]
特徴
- 背景：EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK; PI3 kinase-AKT; PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16; activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P00533
- タグ種類：C-Fc
- アミノ酸配列：Leu25-Ser645
- 遺伝子構造：Recombinant Human Epidermal Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a Fc tag at the C-terminus.
- 活性：Immobilized Human EGF(Cat: PKSH033687) at 10μg/ml(100 μl/well) can bind Human EGFR-Fc.
- 別名（遺伝子名）：Epidermal growth factor receptor; EGFR; Proto-oncogene c-ErbB-1; Receptortyrosine-protein kinase erbB-1; EGFR
- 分子量：95.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106141-Elabscience-PKSH032398.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7780-03
Recombinant Human EGFR/ErbB1 Protein (aa 25-645, Fc Tag)(Active) 10ug
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89-7780-04
Recombinant Human EGFR/ErbB1 Protein (aa 25-645, Fc Tag)(Active) 50ug
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