89-7779-78 ［取扱停止］Recombinant Human EPHA8 Protein (Fc Tag)(Active) 10ug PKSH032386
[Elabscience]
特徴
- 背景：Ephrin type-A receptor 8 (EPHA8) is single-pass type I membrane protein. As receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P29322
- タグ種類：C-Fc
- アミノ酸配列：Ala28-Leu495
- 遺伝子構造：Recombinant Human Ephrin type A receptor 8 is produced by our Mammalian expression system and the target gene encoding Ala28-Leu495 is expressed with a Fc tag at the C-terminus.
- 活性：Immobilized Human EphA8-Fc at 1.5μg/ml(100 μl/well) can bind Mouse EFNA5-His(Cat: PKSM041010). The ED50 of Human EphA8-Fc is 12.63ug/ml .
- 別名（遺伝子名）：Ephrin type-A receptor 8;EEK; HEK3; KIAA1459;EPHA8;Tyrosine-protein kinase receptor EEK;hEK3;EK3;EPH-like kinase 3;EPH- and ELK-related kinase
- 分子量：78.4 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106129-Elabscience-PKSH032386.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7779-79
Recombinant Human EPHA8 Protein (Fc Tag)(Active) 50ug
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89-7779-78
Recombinant Human EPHA8 Protein (Fc Tag)(Active) 10ug
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