89-7779-74 Recombinant Human EphA2 Protein (Fc Tag)(Active) 10ug PKSH032384
[Elabscience]
特徴
- 背景：Ephrin type-A receptor 2/EphA2 is a member of the Eph receptor tyrosine kinase family which binds Ephrins A1; 2; 3; 4; and 5. A and B class Eph proteins have a common structural organization. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells; leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. EphA2 becomes autophosphorylated following ligand binding and then interacts with SH2 domain-containing PI3-kinase to activate MAPK pathways. Reverse signaling is also propagated through the Ephrin ligand. Transcription of EphA2 is dependent on the expression of E-Cadherin; and can be induced by p53 family transcription factors. EphA2 is upregulated in breast; prostate; and colon cancer vascular endothelium. Its ligand; EphrinA1; is expressed by the local tumor cells. In some cases; EphA2 and EphrinA1 are expressed on the same blood vessels. EphA2 signaling cooperates with VEGF receptor signaling in promoting endothelial cell migration.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P29317
- タグ種類：C-Fc
- アミノ酸配列：Ala24-Asn534
- 遺伝子構造：Recombinant Human Ephrin A Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ala24-Asn534 is expressed with a Fc tag at the C-terminus.
- 活性：Immobilized Human Ephrin-A1-His(Cat: PKSH032388) at 1.5μg/ml(100 μl/well) can bind Human EphA2-Fc. The ED50 of Human EphA2-Fc is 12.43 ug/ml.
- 別名（遺伝子名）：Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA2;ARCC2;CTPA;CTPP1;CTRCT6;ECK
- 分子量：83.0 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106127-Elabscience-PKSH032384.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7779-74
Recombinant Human EphA2 Protein (Fc Tag)(Active) 10ug
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89-7779-75
Recombinant Human EphA2 Protein (Fc Tag)(Active) 50ug
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