89-7778-01 Recombinant Human CRTAM /CD355 Protein (His Tag)(Active) 10ug PKSH032286
[Elabscience]
特徴
- 背景：Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNγ or IL-22 production.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：O95727
- タグ種類：C-6His
- アミノ酸配列：Ser18-Ser286
- 遺伝子構造：Recombinant Human Cytotoxic and Regulatory T-Cell Molecule is produced by our Mammalian expression system and the target gene encoding Ser18-Ser286 is expressed with a 6His tag at the C-terminus.
- 活性：Immobilized Mouse CADM1-Fc(Cat: PKSM041213) at 2μg/ml(100 μl/well) can bind Human CRTAM-His. The ED50 of Human CRTAM-His is 4.905 ug/ml .
- 別名（遺伝子名）：Cytotoxic and Regulatory T-Cell Molecule; Class-I MHC-Restricted T-Cell-Associated Molecule; CD355; CRTAM
- 分子量：31.0 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106040-Elabscience-PKSH032286.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7778-01
Recombinant Human CRTAM /CD355 Protein (His Tag)(Active) 10ug
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89-7778-02
Recombinant Human CRTAM /CD355 Protein (His Tag)(Active) 50ug
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