89-7777-18 Recombinant Human Cerberus/CER1 Protein (His Tag) 10ug PKSH032240
[Elabscience]
特徴
- 背景：Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：O95813
- タグ種類：C-6His
- アミノ酸配列：Thr18-Ala267
- 遺伝子構造：Recombinant Human Cerberus 1 is produced by our Mammalian expression system and the target gene encoding Thr18-Ala267 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Cerberus; Cerberus-Related Protein; DAN Domain Family Member 4; CER1; DAND4
- 分子量：29.2 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM HAc.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105999-Elabscience-PKSH032240.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7777-18
Recombinant Human Cerberus/CER1 Protein (His Tag) 10ug
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89-7777-19
Recombinant Human Cerberus/CER1 Protein (His Tag) 50ug
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