89-7774-93 Recombinant Human BTLA/CD272 Protein (Fc Tag)(Active) 10ug PKSH032104
[Elabscience]
特徴
- 背景：B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q7Z6A9
- タグ種類：C-Fc
- アミノ酸配列：Lys31-Leu150
- 遺伝子構造：Recombinant Human B- and T-Lymphocyte Attenuator is produced by our Mammalian expression system and the target gene encoding Lys31-Leu150 is expressed with a Fc tag at the C-terminus.
- 活性：Immobilized Human BTLA-Fc at 2μg/ml(100 μl/well) can bind Human HVEM-His(Cat: PKSH033657).
- 別名（遺伝子名）：B- and T-Lymphocyte Attenuator; B- and T-Lymphocyte-Associated Protein; CD272; BTLA
- 分子量：40.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105888-Elabscience-PKSH032104.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7774-93
Recombinant Human BTLA/CD272 Protein (Fc Tag)(Active) 10ug
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89-7774-94
Recombinant Human BTLA/CD272 Protein (Fc Tag)(Active) 50ug
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