89-7774-76 Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein 50ug PKSH032094
[Elabscience]
特徴
- 背景：Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q15121
- アミノ酸配列：Met 1-Ala130
- 遺伝子構造：Recombinant Human Phosphoprotein Enriched in Astrocytes of 15 kDa is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed.
- 別名（遺伝子名）：Astrocytic Phosphoprotein PEA-15; 15 kDa Phosphoprotein Enriched in Astrocytes; Phosphoprotein Enriched in Diabetes; PED; PEA15
- 分子量：15.3 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105879-Elabscience-PKSH032094.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7774-75
Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein 10ug
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89-7774-76
Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein 50ug
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