特徴
- 背景：Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001706.2
- タグ種類：C-6His
- アミノ酸配列：Gly2-Pro505
- 遺伝子構造：Recombinant Human Tyrosine-Protein Kinase BLK is produced by our E.coli expression system and the target gene encoding Gly2-Pro505 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Tyrosine-Protein Kinase Blk; B Lymphocyte Kinase; p55-Blk; BLK;MODY11
- 分子量：58.7 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 1mM DTT, pH 7.4.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105801-Elabscience-PKSH032011.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7773-27
Recombinant Human BLK Protein (His Tag) 50ug
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89-7773-26
Recombinant Human BLK Protein (His Tag) 10ug
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