89-7773-22 Recombinant Human EphA2 Protein (His Tag)(Active) 10ug PKSH032009
[Elabscience]
特徴
- 背景：Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning; neuronal targeting; vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore; elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature; suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases; which are primarily expressed during development; EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth; survival; migration; and angiogenesis.Unlike other receptor tyrosine kinases; ligand binding is not necessary for EphA2. Rather; the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth; migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells; and that these changes promote metastatic character.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P29317
- タグ種類：C-6His
- アミノ酸配列：Ala24-Asn534
- 遺伝子構造：Recombinant Human Ephrin A Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ala24-Asn534 is expressed with a 6His tag at the C-terminus.
- 活性：Immobilized Human EphA2-His at 4μg/ml(100 μl/well) can bind Human EFNA1-Fc(Cat: PKSH032389). The ED50 of Human EphA2-His is 0.03ug/ml .
- 別名（遺伝子名）：Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA2;ARCC2;CTPA;CTPP1;CTRCT6;ECK
- 分子量：57.0 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105799-Elabscience-PKSH032009.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7773-23
Recombinant Human EphA2 Protein (His Tag)(Active) 50ug
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89-7773-22
Recombinant Human EphA2 Protein (His Tag)(Active) 10ug
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