特徴
- 背景：Interleukin 10(IL10), also known as cytokine synthesis inhibitory factor (CSIF),is a secreted protein andbelongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepaticstellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokinethat has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 inproduced in several T helper populations, it is proposed that it provides a feedback loop to limit theeffector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viablebiomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. Inaddition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviralinfections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possibleclinical use of IL-10 in suppressing rejections of grafts after organ transplantations.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P22301
- アミノ酸配列：Ser19-Asn178
- 遺伝子構造：Recombinant Human Interleukin-10 is produced by our Mammalian expression system and the target gene encoding Ser19-Asn178 is expressed.
- 別名（遺伝子名）：Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11-262N9.1; IL10A; MGC126450; MGC126451; TGIF
- 分子量：19.6 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105795-Elabscience-PKSH032005.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7773-14
Recombinant Human IL-10/Interleukin-10 Protein 10ug
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89-7773-15
Recombinant Human IL-10/Interleukin-10 Protein 50ug
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