89-7773-01 Recombinant Human EGFR/ErbB1 Protein (Fc Tag)(Active) 100ug PKSH031995
[Elabscience]
特徴
- 背景：As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_005219
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Gly 645
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Gly 645) of human EGFR (NP_005219) was fused with the Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized recombinant human EGF at 10 μg/ml (100 μl/well) can bind human EGFR with a linear range of 0.64-400 ng/ml.
- 別名（遺伝子名）：ERBB;ERBB1;HER1;mENA;NISBD2;PIG61
- 分子量：95 kDa
- 組成：Lyophilized from sterile PBS; pH 7.41. Normally 5 % - 8 % trehalose; mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hard copy of CoA.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105785-Elabscience-PKSH031995.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7773-01
Recombinant Human EGFR/ErbB1 Protein (Fc Tag)(Active) 100ug
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89-7772-99
Recombinant Human EGFR/ErbB1 Protein (Fc Tag)(Active) 50ug
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