89-7772-56 ［取扱停止］Recombinant Human IGF-1/IGF-I/IGF1 Protein (Active) 500ug PKSH031965
[Elabscience]
特徴
- 背景：IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
仕様
- サイズ：500ug
- 種由来：Human
- 発現宿主：Yeast
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_001104754.1
- アミノ酸配列：Gly49-Ala118
- 遺伝子構造：A DNA sequence encoding the human IGF1 (NP_001104754.1) (Gly49-Ala118) was expressed.
- 活性：Measured in a cell proliferation assay using MCF-7 cells. The ED50?for this effect is 15-60ng/mL.
- 別名（遺伝子名）：IGF-1;IGF-I;IGF1A;IGFI;IGF‑I;MGF
- 分子量：7.7 kDa
- 組成：Lyophilized from sterile PBS,pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105761-Elabscience-PKSH031965.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7772-56
Recombinant Human IGF-1/IGF-I/IGF1 Protein (Active) 500ug
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89-7772-55
Recombinant Human IGF-1/IGF-I/IGF1 Protein (Active) 100ug
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