89-7772-07 ［取扱停止］Recombinant Human NPM1/Nucleophosmin Protein (His Tag) 50ug PKSH031911
[Elabscience]
特徴
- 背景：Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53. The NPM1 gene is frequently involved in chromosomal translocation, mutation and deletion. Mutations of the NPM1 gene leading to the expression of a cytoplasmic mutant protein, NPMc+, are the most frequent genetic abnormalities found in acute myeloid leukemias. Acute myeloid leukemias (AML) with mutated NPM1 have distinct characteristics, including a significant association with a normal karyotype, involvement of different hematopoietic lineages, a specific gene-expression profile and clinically, a better response to induction therapy and a favorable prognosis. In addition, NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：P06748-1
- タグ種類：N-His
- アミノ酸配列：Met 9-Leu 158
- 遺伝子構造：A DNA sequence encoding the human NPM1 isoform 1 (P06748-1) N-terminal segment (Met 9-Leu 158) was expressed, with a polyhistide tag at the N-terminus.
- 別名（遺伝子名）：B23;NPM
- 分子量：17.8 kDa
- 組成：Lyophilized from sterile PBS, pH 6.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105750-Elabscience-PKSH031911.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7772-07
Recombinant Human NPM1/Nucleophosmin Protein (His Tag) 50ug
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89-7772-08
Recombinant Human NPM1/Nucleophosmin Protein (His Tag) 100ug
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