89-7771-97 Recombinant Human TLR2/CD282 Protein (aa 1-587, His Tag) 100ug PKSH031904
[Elabscience]
特徴
- 背景：TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 contains 14 LRR (leucine-rich) repeats and 1 TIR domain. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. CD282 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It may also promote apoptosis in response to lipoproteins.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：O60603
- タグ種類：C-His
- アミノ酸配列：Met 1-Arg 587
- 遺伝子構造：A DNA sequence encoding the human TLR2 (O60603) extracellular domain (Met 1-Arg 587) was expressed, with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：CD282;TIL4
- 分子量：65.8kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38268-Elabscience-PKSH031904.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7771-97
Recombinant Human TLR2/CD282 Protein (aa 1-587, His Tag) 100ug
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89-7771-96
Recombinant Human TLR2/CD282 Protein (aa 1-587, His Tag) 50ug
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