89-7771-95 ［取扱停止］Recombinant Human CDC42/G25K Protein (GST Tag) 200ug PKSH031903
[Elabscience]
特徴
- 背景：Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53. The NPM1 gene is frequently involved in chromosomal translocation, mutation and deletion. Mutations of the NPM1 gene leading to the expression of a cytoplasmic mutant protein, NPMc+, are the most frequent genetic abnormalities found in acute myeloid leukemias. Acute myeloid leukemias (AML) with mutated NPM1 have distinct characteristics, including a significant association with a normal karyotype, involvement of different hematopoietic lineages, a specific gene-expression profile and clinically, a better response to induction therapy and a favorable prognosis. In addition, NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions.
仕様
- サイズ：200ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：P60953-2
- タグ種類：N-GST
- アミノ酸配列：Met 1-Cys 188
- 遺伝子構造：A DNA sequence encoding the mature form of human CDC42 isoform 2 (P60953-2) (Met 1-Cys 188) was fused with the GST tag at the N-terminus.
- 別名（遺伝子名）：CDC42Hs;G25K
- 分子量：48.1 kDa
- 組成：Lyophilized from sterile 20mM Tris, 0.15M NaCl, 0.5mM GSH, pH 8.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38267-Elabscience-PKSH031903.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7771-95
Recombinant Human CDC42/G25K Protein (GST Tag) 200ug
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89-7771-94
Recombinant Human CDC42/G25K Protein (GST Tag) 100ug
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