89-7771-92 ［取扱停止］Recombinant Human BACE1/ASP2 Protein (Fc Tag)(Active) 50ug PKSH031902
[Elabscience]
特徴
- 背景：Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain; This protein is expressed highly in the substantia nigra; locus coruleus and medulla oblongata. Strong BACE1 expression has also been described in pancreatic tissue. BACE1 has a pivotal role in the pathogenesis of Alzheimer's disease. In Alzheimer's disease patients; BACE1 levels were elevated although mRNA levels were not changed. It has been found that BACE1 gene expression is controlled by a TATA-less promoter. The translational repression as a new mechanism controlling its expression. And the low concentrations of Ca(2+) (microM range) significantly increased the proteolytic activity of BACE1. Furthermore; BACE1 protein is ubiquitinated; and the degradation of BACE1 proteins and amyloid precursor protein processing are regulated by the ubiquitin-proteasome pathway. It has also been identified as the rate limiting enzyme for amyloid-beta-peptide (Abeta) production.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_036236.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Thr 457
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Thr 457) of human BACE1 (NP_036236.1) was expressed as a secreted chimeric protein with the C-terminal fused Fc region of human IgG1.
- 活性：Measured by its ability to cleave a fluorogenic peptide substrate; Mca-SEVNLDAEFRK(Dpn)RR-NH2; (R&D Systems; Catalog # ES004). The specific activity is >0.5 pmoles/min/μg.
- 別名（遺伝子名）：ASP2;BACE;HSPC104
- 分子量：75 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38266-Elabscience-PKSH031902.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7771-93
Recombinant Human BACE1/ASP2 Protein (Fc Tag)(Active) 100ug
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89-7771-92
Recombinant Human BACE1/ASP2 Protein (Fc Tag)(Active) 50ug
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