89-7771-20 ［取扱停止］Recombinant Human DUSP3/VHR Protein (His & GST Tag) 50ug PKSH031862
[Elabscience]
特徴
- 背景：Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP); and the other name is dual-specificity phosphatase 3 (DUSP3). DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Unlike typical DUSPs; VHR lacks mitogen-activated protein kinase (MAPK)-binding domain; and shows poor activity against MAPKs. VHR often act on bisphosphorylated protein substrates; it displays a strong preference for dephosphorylating phosphotyrosine residues over phosphothreonine residues. VHR has been identified as a novel regulator of extracellular regulated kinases (ERKs). VHR is responsible for the rapid inactivation of ERK following stimulation and for its repression in quiescent cells. VHR is a negative regulator of the Erk and Jnk pathways in T cells and; therefore; may play a role in aspects of T lymphocyte physiology that depend on these kinases.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 96 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P51452
- タグ種類：N-His & GST
- アミノ酸配列：Met 1-Pro 185
- 遺伝子構造：A DNA sequence encoding the human VHR (P51452) (Met 1-Pro 185) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 別名（遺伝子名）：Dual specificity protein phosphatase 3;DUSP3;Dual specificity protein phosphatase VHR;Vaccinia H1-related phosphatase;VHR
- 分子量：48.3 kDa
- 組成：Lyophilized from sterile 20mM Tris; 500mM NaCl; pH 8.0; 2mM GSH
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38239-Elabscience-PKSH031862.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7771-21
Recombinant Human DUSP3/VHR Protein (His & GST Tag) 100ug
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89-7771-20
Recombinant Human DUSP3/VHR Protein (His & GST Tag) 50ug
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