89-7770-45 ［取扱停止］Recombinant Human Cathepsin Z Protein (His Tag)(Active) 10ug PKSH031822
[Elabscience]
特徴
- 背景：Cathepsin Z (CTSZ); also known as Cathepsin X or CATX; belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus; and in contrast to cathepsin B; it does not act as an endopeptidase. It is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues; suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells; a process; which is crucial in the initiation of adaptive immunity. Furthermore; higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa; especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources; suggesting that this enzyme may participate in tumor progression.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q9UBR2
- タグ種類：C-His
- アミノ酸配列：Met 1-Val 303
- 遺伝子構造：A DNA sequence encoding the human CTSZ (Q9UBR2) (Met 1-Val 303) was fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its ability to cleave the fluorogenic peptide substrate; Mca-RPPGFSAFK (Dnp)-OH;R&D Systems; Catalog # ES005.The specific activity is >800 pmoles/min/μg.
- 別名（遺伝子名）：Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ
- 分子量：33 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38207-Elabscience-PKSH031822.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7770-45
Recombinant Human Cathepsin Z Protein (His Tag)(Active) 10ug
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89-7770-46
Recombinant Human Cathepsin Z Protein (His Tag)(Active) 20ug
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