89-7770-12 Recombinant Human Contactin 3/CNTN3 Protein (708 Asp/Asn, Fc Tag)(Active) 100ug PKSH031803
[Elabscience]
特徴
- 背景：Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1; Contactin-2(TAG-1); Contactin-3(BIG-1); BIG-2; Contactin-5(NB-2) and NB-3. Since their identification in the late 1980s; Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast; the function of the other four members of this subgroup remained unknown until recently. Contactin-3; also known as CNTN3 ( BIG-1 in rat and PANG in mouse ); is a GPI-linked glycoprotein that is expressed on cerebellar Purkinje cells; amygdaloid and thalamic neurons and olfactory granule cells. In the brain; Contactin-3 is expressed in frontal lobe; occipital lobe; cerebellum and amygdala. Contactin-3 contains 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. Human Contactin-3 shares 92% aa identity with mouse Contactin-3.The exact function of Contactin-3 is unclear. Contactin-3 may mediate cell-cell interaction and may promote neurite outgrowth.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_065923.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Ser 1002; 708 Asp/Asn
- 遺伝子構造：A DNA sequence encoding the human CNTN3 precursor (NP_065923.1) (Met 1-Ser 1002; 708 Asp/Asn) was expressed with the fused Fc region of human IgG1 at the C-terminus.
- 活性：Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. When 5 x 10E4 cells/well are added to CNTN3 coated plates (0.8 μg/ml and 100 μl/well); approximately 30%-50% will adhere specifically after 60 minutes at 37℃.
- 別名（遺伝子名）：BIG-1;PANG;PCS
- 分子量：134.5 kDa
- 組成：Lyophilized from sterile 100mM Glycine; 10mM NaCl; 50mM Tris; pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38191-Elabscience-PKSH031803.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7770-11
Recombinant Human Contactin 3/CNTN3 Protein (708 Asp/Asn, Fc Tag)(Active) 50ug
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89-7770-12
Recombinant Human Contactin 3/CNTN3 Protein (708 Asp/Asn, Fc Tag)(Active) 100ug
|
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