89-7769-83　Recombinant Human S100B Protein (His Tag)(Active) 100ug　PKSH031788

特徴

• 背景：S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation; which might have important implications during brain; cartilage and skeletal muscle development and repair; activation of astrocytes in the course of brain damage and neurodegenerative processes; and of cardiomyocyte remodeling after infarction; as well as in melanomagenesis and gliomagenesis. As an extracellular factor; S100B engages RAGE (receptor for advanced glycation end products) in a variety of cell types with different outcomes (i.e. beneficial or detrimental; pro-proliferative or pro-differentiative) depending on the concentration attained by the protein; the cell type and the microenvironment. This calcium binding astrocyte-specific cytokine; presents a marker of astrocytic activation and reflects CNS injury. The excellent sensitivity of S100B has enabled it to confirm the existence of subtle brain injury in patients with mild head trauma; strokes; and after successful resuscitation from cardiopulmonary arrest. Recent findings provide evidence; that S100B may decrease neuronal injury and/or contribute to repair following traumatic brain injury (TBI). Hence; S100B; far from being a negative determinant of outcome; as suggested previously in the human TBI and ischemia literature; is of potential therapeutic value that could improve outcome in patients who sustain various forms of acute brain damage.