89-7769-52 ［取扱停止］Recombinant Human JAM-A/F11R Protein (His Tag)(Active) 50ug PKSH031771
[Elabscience]
特徴
- 背景：Junctional adhesion molecule-A (JAM-A); also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321); is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells; as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1; involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily; JAM-A protein involves in platelet adhesion; secretion and aggregation; and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition; it may be a potential therapeutic target for breast cancer.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_058642.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ala 242
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Ala 242) of human JAM-A (NP_058642.1) precursor was expressed with a polyhistidine tag at the C-terminus.
- 活性：Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8 x 104 cells/well are added to JAM-A-Fc coated plates (2.5μg/mL; 100 μL/well)in the presence of 20 ng/mL PMA; approximately 30-40% will adhere after 30 minutes at 37℃.
- 別名（遺伝子名）：Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM;JAMA;JCAM;KAT
- 分子量：25 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38165-Elabscience-PKSH031771.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7769-53
Recombinant Human JAM-A/F11R Protein (His Tag)(Active) 100ug
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89-7769-52
Recombinant Human JAM-A/F11R Protein (His Tag)(Active) 50ug
|
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