89-7769-50 ［取扱停止］Recombinant Human Kallikrein 13/KLK13 Protein (His Tag)(Active) 10ug PKSH031770
[Elabscience]
特徴
- 背景：Tissue kallikrein 13 (hK13); also known as KLK-L4 (kallikrein-like gene 4); is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like; secreted serine protease expressed specifically in the testicular tissue including prostate; salivary gland; breast; and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers; and is regarded as a novel cancer biomarker. In addition; KLK13 interacts and forms complexes with several serum protease inhibitors; such as alpha2-macroglobulin; and its expression is regulated by steroid hormones.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_056411.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ile 262
- 遺伝子構造：A DNA sequence encoding the pro-form of human KLK13 (NP_056411.1) (Met 1-Ile 262) was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC (R&D Systems; Catalog # ES011). The specific activity is >200 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by Lysyl-Endopeptidase for an activated form)
- 別名（遺伝子名）：Kallikrein-13; Kallikrein-Like Protein 4; KLK-L4; KLK13; KLKL4
- 分子量：28.4 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38164-Elabscience-PKSH031770.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7769-50
Recombinant Human Kallikrein 13/KLK13 Protein (His Tag)(Active) 10ug
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89-7769-51
Recombinant Human Kallikrein 13/KLK13 Protein (His Tag)(Active) 20ug
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