89-7769-22 ［取扱停止］Recombinant Human Latexin/LXN Protein (Fc Tag) 10ug PKSH031756
[Elabscience]
特徴
- 背景：Latexin; also known as endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor; TCI; ECI and LXN; is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart; prostate; ovary; kidney; pancreas; and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart; prostate; ovary; kidney; pancreas; and colon; but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets; and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors; Latexin is related to a human putative tumor suppressor protein; TIG1. In addition; Latexin is also implicated in Alzheimer's disease.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_064554.3
- タグ種類：N-Fc
- アミノ酸配列：Glu 2-Glu 222
- 遺伝子構造：A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu 222) was fused with the Fc region of human IgG1 at the N-terminus.
- 別名（遺伝子名）：ECI;TCI
- 分子量：52 kDa
- 組成：Lyophilized from sterile 100mM Glycine; 10mM NaCl; 50mM Tris; pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38153-Elabscience-PKSH031756.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7769-22
Recombinant Human Latexin/LXN Protein (Fc Tag) 10ug
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89-7769-23
Recombinant Human Latexin/LXN Protein (Fc Tag) 20ug
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