89-7769-06 ［取扱停止］Recombinant Human G-CSFR/CD114 Protein (His Tag)(Active) 50ug PKSH031748
[Elabscience]
特徴
- 背景：Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_000751.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Pro 621
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Pro 621) of human G-CSF receptor (NP_000751.1) precursor was fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its ability to inhibit the GCSF-induced proliferation of NFS60 mouse myeloid cells.The ED50 for this ettect is typically 50-250 ng/mL in the presence of 0.125ng/mL of recombinant human GCSF.
- 別名（遺伝子名）：CD114;CSF3R;G-CSF R;GCSFR
- 分子量：68 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38146-Elabscience-PKSH031748.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7769-07
Recombinant Human G-CSFR/CD114 Protein (His Tag)(Active) 100ug
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89-7769-06
Recombinant Human G-CSFR/CD114 Protein (His Tag)(Active) 50ug
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