89-7768-29 ［取扱停止］Recombinant Human Galectin-3/LGALS3 Protein, Low Endotoxin(Active) 10ug PKSH031707
[Elabscience]
特徴
- 背景：Leukotriene A-4 hydrolase; also known as LTA-4 hydrolase; Leukotriene A (4) hydrolase; LTA4H and LTA4; is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs; arachidonic acid was converted into the unstable intermediate epoxide LTA4; which may in turn be conjugated with glutathione to form the spasmogenic LTC4; or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium; and also modulates immune responses. As a bifunctional zinc metalloenzyme; LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 5 EU per 1 mg of the protein as determined by the LAL method.
- アクセッションＮｏ．：P17931
- アミノ酸配列：Met 1-Ile 250
- 遺伝子構造：A DNA sequence encoding the human Galectin3 (P17931) (Met 1-Ile 250) was expressed and purified.
- 活性：Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 3-15 μg/ml.
- 別名（遺伝子名）：Galectin-3; Gal-3; 35 kDa Lectin; Carbohydrate-Binding Protein 35; CBP35; Galactose-Specific Lectin 3; Galactoside-Binding Protein; GALBP; IgE-Binding Protein; L-31; Laminin-Binding Protein; Lectin L-29; Mac-2 Antigen; LGALS3; MAC2; P35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2
- 分子量：26.1 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38119-Elabscience-PKSH031707.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7768-29
Recombinant Human Galectin-3/LGALS3 Protein, Low Endotoxin(Active) 10ug
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89-7768-30
Recombinant Human Galectin-3/LGALS3 Protein, Low Endotoxin(Active) 20ug
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