89-7767-63 ［取扱停止］Recombinant Human IFNGR1 Protein (His & Fc Tag)(Active) 200ug PKSH031671
[Elabscience]
特徴
- 背景：The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interteron receptor while IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.
仕様
- サイズ：200ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_000407.1
- タグ種類：C-His & Fc
- アミノ酸配列：Met 1-Gly 245
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Gly 245) of human IFN-γ receptor 1 pre-protein (NP_000407.1) was fused with C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its ability to inhibit rhIFNγ mediated protection of WISH cells infected with vesicular stomatitis virus(VSV).The ED50 for this effect is typically 0.4-2 μg/mL.
- 別名（遺伝子名）：CD119;IFNGR;IMD27A;IMD27B;Interferon gamma receptor 1;IFNGR1
- 分子量：53.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105695-Elabscience-PKSH031671.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7767-62
Recombinant Human IFNGR1 Protein (His & Fc Tag)(Active) 100ug
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89-7767-63
Recombinant Human IFNGR1 Protein (His & Fc Tag)(Active) 200ug
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