89-7767-30 ［取扱停止］Recombinant Human RBP4 Protein (His Tag)(Active) 50ug PKSH031655
[Elabscience]
特徴
- 背景：Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A); and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily; RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver; and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma; the RBP4-retinol complex interacts with transthyretin (TTR); and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes; and its deficiency affects night vision largely. Recently; RBP4 as an adipokine; is found to be expressed in adipose tissue and correlated with obesity; insulin resistance (IR) and type 2 diabetes (T2DM).
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_006735.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Leu 201
- 遺伝子構造：A DNA sequence encoding the pro form of human RBP4 (NP_006735.2) (Met 1-Leu 201) was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its ability to bind all-trans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.The 50% binding concentration (BC50) is > 1.0 uM
- 別名（遺伝子名）：RDCCAS;Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP; RBP4
- 分子量：
- 組成：Lyophilized from sterile PBS; pH 7.2
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38082-Elabscience-PKSH031655.pdf
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89-7767-30
Recombinant Human RBP4 Protein (His Tag)(Active) 50ug
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89-7767-31
Recombinant Human RBP4 Protein (His Tag)(Active) 100ug
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