89-7767-22 ［取扱停止］Recombinant Human/Rhesus HER4/ErbB4 Protein (Fc Tag)(Active) 50ug PKSH031650
[Elabscience]
特徴
- 背景：ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains; a transmembrane domain; a tyrosine kinase domain; a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain; heart; kidney; in addition to skeletal muscle; parathyroid; cerebellum; pituitary; spleen; testis and breast. And lower levels in thymus; lung; salivary gland; and pancreas. It specifically binds to and is activated by neuregulins; NRG-2; NRG-3; heparin-binding EGF-like growth factor; betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart; the central nervous system and the mammary gland; gene transcription; cell proliferation; differentiation; migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development; and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system; especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation; induction of milk proteins and lactation.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_005226.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Arg649
- 遺伝子構造：A DNA sequence encoding the human ERBB4 (NP_005226.1) (Met1-Arg649) was expressed; fused with the Fc region of human IgG1 at the C-terminus.Human and Rhesus ERBB4 sequences are identical.
- 活性：1. Measured by its ability to bind biotinylated human Fc-NRG1 (isoform Beta1) in a functional ELISA.2. Measured by its ability to bind biotinylated human NRG1 (isoform Beta1) in a functional ELISA.3. Measured by its ability to bind biotinylated human NRG1 (aa 2-246)-Fc in a functional ELISA.
- 別名（遺伝子名）：Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; ERBB4; HER4
- 分子量：96.6 kDa
- 組成：Lyophilized from sterile PBS; pH7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38080-Elabscience-PKSH031650.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7767-23
Recombinant Human/Rhesus HER4/ErbB4 Protein (Fc Tag)(Active) 100ug
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89-7767-22
Recombinant Human/Rhesus HER4/ErbB4 Protein (Fc Tag)(Active) 50ug
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