89-7767-20 ［取扱停止］Recombinant Human HER4/ErbB4 Protein (His & Fc Tag)(Active) 50ug PKSH031649
[Elabscience]
特徴
- 背景：ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. And lower levels in thymus, lung, salivary gland, and pancreas. It specifically binds to and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation, induction of milk proteins and lactation.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001036064.1
- タグ種類：C-His & Fc
- アミノ酸配列：Met 1-Pro 651
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Pro 651) of human ErbB4 precursor (NP_001036064.1) was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus.
- 活性：1.Measured by its ability to bind biotinylated human Fc-NRG1 (isoform Beta 1) in a functional ELISA.2. Measured by its ability to bind with biotinylated human NRG1 (isoform Beta 1)in a functional ELISA.3. Measured by its ability to bind with biotinylated human NRG1 (aa 2-246)-Fc in a functional ELISA.4. Measured by its ability to bind with biotinylated human NRG1 (aa 20-241)-His in a functional ELISA.
- 別名（遺伝子名）：Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; ERBB4; HER4
- 分子量：97.5 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38079-Elabscience-PKSH031649.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7767-20
Recombinant Human HER4/ErbB4 Protein (His & Fc Tag)(Active) 50ug
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89-7767-21
Recombinant Human HER4/ErbB4 Protein (His & Fc Tag)(Active) 100ug
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