89-7766-67 ［取扱停止］Recombinant Human Hemojuvelin/HFE2 Protein (His Tag) 50ug PKSH031623
[Elabscience]
特徴
- 背景：Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q6ZVN8-1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 399
- 遺伝子構造：A DNA sequence encoding the mature form of human HFE2 isoform a (Q6ZVN8-1) (Met 1-Ser 399) was fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：HFE2A;HJV;JH;RGMC
- 分子量：40 kDa
- 組成：Lyophilized from sterile PBS, 500mM NaCl, pH 7.0, 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38059-Elabscience-PKSH031623.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7766-68
Recombinant Human Hemojuvelin/HFE2 Protein (His Tag) 100ug
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89-7766-67
Recombinant Human Hemojuvelin/HFE2 Protein (His Tag) 50ug
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