89-7765-95 ［取扱停止］Recombinant Human NCR3/NKp300 Protein (His & Fc Tag)(Active) 50ug PKSH031580
[Elabscience]
特徴
- 背景：Natural Cytotoxicity Triggering Receptor 3; NCR3; also known as NKp30; or CD337; is a natural cytotoxicity receptor; expressed on subsets of human peripheral blood NK cells; involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive; but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity; and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_667341.1
- タグ種類：C-His & Fc
- アミノ酸配列：Met 1-Gly 135
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Gly 135) of human NCR3 (NP_667341.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized human B7-H6 -His at 10μg/mL (100μL/well) can bind human NCR3-Fch; the EC50 of human NCR3-Fch is 6-200ng/mL.
- 別名（遺伝子名）：Natural Cytotoxicity Triggering Receptor 3; Activating Natural Killer Receptor p30; Natural Killer Cell p30-Related Protein; NK-p30; NKp30; CD337; NCR3; 1C7; LY117;1C7;DAAP-90L16.3;MALS
- 分子量：41 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38026-Elabscience-PKSH031580.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7765-95
Recombinant Human NCR3/NKp300 Protein (His & Fc Tag)(Active) 50ug
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89-7765-94
Recombinant Human NCR3/NKp300 Protein (His & Fc Tag)(Active) 20ug
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