89-7765-52 ［取扱停止］Recombinant Human PDGFRB/CD140b Protein (Active) 100ug PKSH031556
[Elabscience]
特徴
- 背景：The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_002600.1
- アミノ酸配列：Met 1-Lys 531
- 遺伝子構造：A DNA sequence encoding the extracellular domain of human PDGFRβ (NP_002600.1) (Met 1-Lys 531) was expressed with six amino acids (ENLYFQ) at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized human PDGFRβ at 10 μg/ml (100 μl/well) can bind Cynomolgus PDGFB , The EC50 of Cynomolgus PDGFB is 3-7 ng/ml.
- 別名（遺伝子名）：Platelet-Derived Growth Factor Receptor Beta; PDGF-R-Beta; PDGFR-Beta; Beta Platelet-Derived Growth Factor Receptor; Beta-Type Platelet-Derived Growth Factor Receptor; CD140 Antigen-Like Family Member B; Platelet-Derived Growth Factor Receptor 1; PDGFR-1; CD140b; PDGFRB; PDGFR; PDGFR1;CD140B;IBGC4;IMF1;JTK12;KOGS;PENTT
- 分子量：57.1 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38008-Elabscience-PKSH031556.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7765-52
Recombinant Human PDGFRB/CD140b Protein (Active) 100ug
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89-7765-53
Recombinant Human PDGFRB/CD140b Protein (Active) 200ug
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