89-7765-37 Recombinant Human CD208/LAMP3/DC-LAMP Protein (His Tag) 100ug PKSH031547
[Elabscience]
特徴
- 背景：Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_055213.2
- タグ種類：C-His
- アミノ酸配列：Lys 28-Thr 381
- 遺伝子構造：A DNA sequence encoding the mature form of human LAMP3 (NP_055213.2) (Lys 28-Thr 381) with a carboxy-terminal polyhistidine tag was expressed.
- 別名（遺伝子名）：CD208;DC LAMP;DC-LAMP;DCLAMP;LAMP;LAMP-3;TSC403
- 分子量：39 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38001-Elabscience-PKSH031547.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7765-37
Recombinant Human CD208/LAMP3/DC-LAMP Protein (His Tag) 100ug
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89-7765-36
Recombinant Human CD208/LAMP3/DC-LAMP Protein (His Tag) 20ug
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