89-7765-06 ［取扱停止］Recombinant Human IL2RG/CD132 Protein (His Tag)(Active) 50ug PKSH031530
[Elabscience]
特徴
- 背景：The common gamma chain (γc) (or CD132); also known as interleukin-2 receptor subunit gamma or IL2RG; is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations; and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG); is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2; IL-4; IL-7; IL-9; IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG; the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data; the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor; together with the finding that IL-2R gamma associates with the IL-7 receptor; begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development; as seen in X-linked severe combined immunodeficiency.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：P31785
- タグ種類：C-His
- アミノ酸配列：Met 1-Asn 254
- 遺伝子構造：A DNA sequence encoding the human IL2RG (P31785) extracellular domain (Met 1-Asn 254) was expressed; fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its ability to bind biotinylated recombinant rat IL2 in a functional ELISA.
- 別名（遺伝子名）：Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; gammaC; P64; CD132; IL2RG; SCIDX;SCIDX1; CIDX
- 分子量：28.8 kDa
- 組成：Lyophilized from sterile 20mM Tris; 500mM NaCl; pH 7.4; 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105660-Elabscience-PKSH031530.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7765-07
Recombinant Human IL2RG/CD132 Protein (His Tag)(Active) 100ug
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89-7765-06
Recombinant Human IL2RG/CD132 Protein (His Tag)(Active) 50ug
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