89-7764-77 ［取扱停止］Recombinant Human ALK4/ACVR1B Protein (His & Fc Tag)(Active) 100ug PKSH031516
[Elabscience]
特徴
- 背景：ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor; type 1B); belongs to the protein kinase superfamily; TKL Ser/Thr protein kinase family; and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB; while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin; type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4; in turn; transduces signals downstream by phosphorylation of its effectors; such as Smads; to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development; with roles in mesoderm induction; primitive streak formation; gastrulation; dorsoanterior patterning; and left-right axis determination.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 80 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_004293.1
- タグ種類：C-His & Fc
- アミノ酸配列：Met 1-Glu 126
- 遺伝子構造：A DNA sequence encoding the human ACVR1B (NP_004293.1) extracellular domain (Met 1-Glu 126) was fused with C-terminal His-tagged Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized human TDGF1 at 2 μg/ml (100 μl/well) can bind human ALK-4 with a linear range of 0.0068-0.16 μg/ml.
- 別名（遺伝子名）：Activin Receptor Type-1B; Activin Receptor Type IB; ACTR-IB; Activin Receptor-Like Kinase 4; ALK-4; Serine/Threonine-Protein Kinase Receptor R2; SKR2; ACVR1B; ACVRLK4; ALK4
- 分子量：39.6 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37983-Elabscience-PKSH031516.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7764-77
Recombinant Human ALK4/ACVR1B Protein (His & Fc Tag)(Active) 100ug
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89-7764-78
Recombinant Human ALK4/ACVR1B Protein (His & Fc Tag)(Active) 200ug
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