89-7764-76 ［取扱停止］Recombinant Human Interleukin-21/IL-21 Protein (Active) 20ug PKSH031514
[Elabscience]
特徴
- 背景：IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation)Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 92 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：Q9HBE4-1
- アミノ酸配列：Gln 23-Ser 155
- 遺伝子構造：A DNA sequence encoding the mature form of human IL-21 isoform 1 (Q9HBE4-1) (Gln 23-Ser 155) was expressed and purified, with an initial Met.
- 活性：1. Measured by its ability to bind human IL-21R in a functional ELISA.2. Measured by its ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.4-2 ng/ml.
- 別名（遺伝子名）：Interleukin-21;IL-21; Za11; IL21
- 分子量：15.6 kDa
- 組成：Lyophilized from sterile 20mM NaAc, 150mM NaCl, pH 5.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37981-Elabscience-PKSH031514.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7764-76
Recombinant Human Interleukin-21/IL-21 Protein (Active) 20ug
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89-7764-75
Recombinant Human Interleukin-21/IL-21 Protein (Active) 5ug
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