89-7764-50 ［取扱停止］Recombinant Human SerpinB2/PAI-2 Protein (GST Tag)(Active) 20ug PKSH031499
[Elabscience]
特徴
- 背景：Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB2 is a major product of activated monocytes and macrophages and is substantially induced during most inflammatory processes. Distinct from its widely described extracellular role as an inhibitor of urokinase plasminogen activator. SerpinB2 has been shown to have an intracellular role as a retinoblastoma protein (Rb)-binding protein that inhibits Rb degradation. SerpinB2 is widely described as an inhibitor of urokinase plasminogen activator. SerpinB2 inhibits urokinase-type plasminogen activator. The monocyte derived SerpinB2 is distinct from the endothelial cell-derived PAI-1. SerpinB2 is a potentially important inducible host factor that significantly promotes HIV-1 replication.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_002566.1
- タグ種類：N-GST
- アミノ酸配列：Met 1-Pro 415
- 遺伝子構造：A DNA sequence encoding the full length of human SERPINB2 (NP_002566.1) (Met 1-Pro 415) was fused with the GST tag at the N-terminus.
- 活性：Immobilized human GST-SerpinB2 at 10 μg/ml (100 μl/well) can bind biotinylated human uPA-His (Cat: PKSH031415), The EC50 of biotinylated human uPA-His is 10.24-23.88 ng/ml.
- 別名（遺伝子名）：HsT1201;PAI;PAI-2;PAI2;PLANH2
- 分子量：73 kDa
- 組成：Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0, 0.5mM Reduced Glutathione, 10% glycerol, 0.5mM PMSF
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37972-Elabscience-PKSH031499.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7764-51
Recombinant Human SerpinB2/PAI-2 Protein (GST Tag)(Active) 50ug
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89-7764-50
Recombinant Human SerpinB2/PAI-2 Protein (GST Tag)(Active) 20ug
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