89-7764-47 Recombinant Human CDC37/CDC37A Protein (GST Tag) 50ug PKSH031497
[Elabscience]
特徴
- 背景：CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_008996.1
- タグ種類：C-GST
- アミノ酸配列：Met 1-Val 378
- 遺伝子構造：A DNA sequence encoding the full length of human CDC37 (NP_008996.1) (Met 1-Val 378) was fused with the GST tag at the C-terminus.
- 別名（遺伝子名）：P50CDC37
- 分子量：70.7 kDa
- 組成：Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM GSH, 0.5mM PMSF, 10% glycerol, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105647-Elabscience-PKSH031497.pdf
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89-7764-46
Recombinant Human CDC37/CDC37A Protein (GST Tag) 20ug
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89-7764-47
Recombinant Human CDC37/CDC37A Protein (GST Tag) 50ug
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