89-7764-40 ［取扱停止］Recombinant Human ULBP1/N2DL1 Protein (His & Fc Tag)(Active) 50ug PKSH031493
[Elabscience]
特徴
- 背景：UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor; NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially functional proteins; and have tissue-specific expressions. ULBP1; also known as RAET1I and NKG2DL1; together with at least ULBP 2 and 3; are well-known ligands for NKG2D; and activate multiple signaling pathways in primary NK cells; resulting in the production of cytokines and chemokines. ULBP1 is expressed in T-cells; B-cells; erythroleukemia cell lines and in a wide range of tissues including heart; brain; lung; liver and bone marrow; as well as some tumor cells. As an unconventional member of the MHC class I family; ULBP1 function in immune responses; especially in cancer and infectious diseases. Unlike other ULBP members; ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor; and thus might escape the immune surveillance. Furthermore; UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_079494.1
- タグ種類：C-His & Fc
- アミノ酸配列：Met 1-Gly 216
- 遺伝子構造：A DNA sequence encoding the mature form of human ULBP1 (NP_079494.1) (Met 1-Gly 216) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 活性：Immobilized human His-NKG2D (78-216) at 10 μg/ml (100 μl/well) can bind human ULBP1-Fch; The EC50 of human ULBP1-Fch is 0.04-0.08 μg/ml.
- 別名（遺伝子名）：RAET1I
- 分子量：50.4 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37969-Elabscience-PKSH031493.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7764-40
Recombinant Human ULBP1/N2DL1 Protein (His & Fc Tag)(Active) 50ug
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89-7764-41
Recombinant Human ULBP1/N2DL1 Protein (His & Fc Tag)(Active) 100ug
|
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