89-7764-13 ［取扱停止］Recombinant Human CD122/IL-2RB Protein (Fc Tag)(Active) 20ug PKSH031479
[Elabscience]
特徴
- 背景：Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_000869.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Asp 239
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Asp 239) of human IL2 Rβ (NP_000869.1) precursor was expressed with the C-terminal fused Fc region of human IgG1.
- 活性：1.Measured by its ability to bind biotinylated recombinant rat IL2 in a functional ELISA.2. Using the Octet RED System, the affinity constant (Kd) of Human IL2RB-Fc bound to Human IL2 was 0.8nM.
- 別名（遺伝子名）：CD122;IL15RB;P70-75
- 分子量：51.6 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37959-Elabscience-PKSH031479.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7764-12
Recombinant Human CD122/IL-2RB Protein (Fc Tag)(Active) 10ug
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89-7764-13
Recombinant Human CD122/IL-2RB Protein (Fc Tag)(Active) 20ug
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