89-7763-82 Recombinant Human EPO Receptor/EPOR Protein (Fc Tag)(Active) 100ug PKSH031462
[Elabscience]
特徴
- 背景：Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type â… single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_000112.1
- タグ種類：C-Fc
- アミノ酸配列：Met-Pro 250
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met-Pro 250) of human erythropoietin receptor (NP_000112.1) precursor was expressed with the C-terminal fused Fc region of human IgG1.
- 活性：1. Measured by its binding ability in a functional ELISA. Immobilized CD131 at 10 μg/ml (100 μl/well) can bind biotinylated recombinant human EPOR with a linear range of 0.16-4 μg/ml.2. Measured by its ability to inhibit Epodependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 1-4 ng/ml in the presence of 0.1 U/mL Recombinant Human EPO.
- 別名（遺伝子名）：EPO-R
- 分子量：51.0 kDa
- 組成：Lyophilized from sterile PBS, 8% sucrose, 0.5% Tween-20, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37948-Elabscience-PKSH031462.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7763-81
Recombinant Human EPO Receptor/EPOR Protein (Fc Tag)(Active) 50ug
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89-7763-82
Recombinant Human EPO Receptor/EPOR Protein (Fc Tag)(Active) 100ug
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